Discovery of Silent Estrogen

A Major Discovery:

“Silent Estrogen” – Estrogenic Substances with No Cell Proliferation

Until now, there was no way to properly analyze and investigate the properties of estrogenic substances found in our daily living environment such as chemicals, cosmetics, and the raw materials used in health foods, so those properties have remained unconfirmed. However, the new test method developed by Scinet now makes it possible to precisely investigate and confirm indicators of estrogenic activity, unable to be confirmed using conventional in vivo animal experimentation, by analyzing uterine hypertrophy in small test animals such as mice.

As a result, Scinet has been the first to confirm the presence of estrogenic substances, but without cell proliferation, among petroleum components and phytoestrogens. We have named these substances as “silent estrogens”. Our research on “silent estrogens” has been published in Europe and the US, and this discovery is expected to become increasingly important going forward.

Silent estrogens have already been discovered in compounds such as petroleum C (Bunker C) residual fuel oil and the Agaricus (mushroom) extract. However, by using the silent estrogens, it is now possible to identify the function of cell proliferation in Brefeldin A (a lactone antiviral produced by Eupenicillium brefeldianum, an anamorph fungus of the Penicillium genus), a component derived from the extract of Agaricus mushrooms, which we anticipate can be used to develop pharmaceuticals and health foods with minimal side effects.

In addition, new studies are required to further understand the significance of “silent estrogens” discovered in environmental pollution such as with the decomposition of heavy oil C.